Drug update

Cholinesterase inhibitors and Alzheimer’s disease

Drug update

Cholinesterase inhibitors and Alzheimer’s disease

Helen M Creasey

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Abstract

Cholinesterase inhibitors may lead to improvement in the symptoms of Alzheimer’s disease, but there is no direct evidence that they alter the long term outcome.

Article Extract

What are cholinesterase inhibitors?

Cholinesterase inhibitors block cholinesterases, enzymes that break down acetylcholine in the synaptic space, thereby allowing acetylcholine to act longer on the post-synaptic receptor. Acetylcholine is a major neurotransmitter for memory, attention and concentration.