Dermatology clinic

A teenager with a blistering skin eruption

Andrew Lee, Gayle Fischer
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Test your diagnostic skills in our regular dermatology quiz. What is the cause of this severe blistering disorder and how should it be treated?

Article Extract

Case presentation

An 18-year-old man presents with a three-month history of a severe itchy, blistering eruption involving his trunk, upper limbs and oral mucosa (Figure). He had been previously well.

At first presentation, skin swabs had been taken and demonstrated Staphylococcus aureus. The patient had been treated with two courses of oral flucloxacillin, but the eruption has not improved.

What is the most likely diagnosis?