The aims of investigation of patients with venous thromboembolic disease (VTE) are to identify occult predisposing conditions, estimate the probability of recurrence and direct further management.
- Venous thromboembolism (VTE) is multifactorial, with both congenital and acquired risk factors.
- VTE may be the first presentation of systemic illness.
- It is not necessary to investigate patients who have VTE following recent major surgery or other identified temporal risk factors.
- Investigating for underlying systemic disease should be guided by careful history, examination and consideration of risk factors.
- Identifying single gene defects, such as factor V Leiden, usually does not change management.
- Specialist advice is suggested for multiple inherited defects or strongly thrombophilic defects, such as antithrombin deficiency.