Not everyone with dry eyes and dry mouth has Sjögren’s syndrome; the differential diagnosis is broad, and patients with this condition present with a wide range of symptoms and spectrum of disease. The prognosis is largely determined by the extent of systemic disease, although exocrine manifestations can have a severe impact on a patient’s quality of life.
Sjögren’s syndrome is a common autoimmune disorder characterised by the destruction of lacrimal and salivary gland function leading to the classic symptoms of keratoconjunctivitis sicca (dry eyes) and xerostomia (dry mouth).1 It can occur alone in primary form, which will be discussed here, or in a secondary form with other rheumatological diseases, most commonly rheumatoid arthritis but also others such as systemic lupus erythematosus (SLE), systemic sclerosis or an inflammatory myopathy.2
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