Dermatology clinic

A child with severe wrinkling of the skin of the palms

GEOFFREY LEE, Gayle Fischer
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Test your diagnostic skills in our regular dermatology quiz. What is the cause of this child’s rapid and severe skin wrinkling that affects her palms after exposure to a small amount of water?

Article Extract

Case presentation
A 12-year-old girl presents with a lifelong history of rapid severe wrinkling of the skin of her palms after minimal exposure to water. The episodes are asymptomatic and self-resolve within 40 to 60 minutes after drying. Her soles are not affected.