Dermatology clinic

A child with severe wrinkling of the skin of the palms

GEOFFREY LEE, Gayle Fischer



Test your diagnostic skills in our regular dermatology quiz. What is the cause of this child’s rapid and severe skin wrinkling that affects her palms after exposure to a small amount of water?

Article Extract

Case presentation
A 12-year-old girl presents with a lifelong history of rapid severe wrinkling of the skin of her palms after minimal exposure to water. The episodes are asymptomatic and self-resolve within 40 to 60 minutes after drying. Her soles are not affected.