Peer Reviewed
Drug update

Cholinesterase inhibitors and Alzheimer’s disease

Helen M Creasey
Abstract
Cholinesterase inhibitors may lead to improvement in the symptoms of Alzheimer’s disease, but there is no direct evidence that they alter the long term outcome.
Key Points
    What are cholinesterase inhibitors?

    Cholinesterase inhibitors block cholinesterases, enzymes that break down acetylcholine in the synaptic space, thereby allowing acetylcholine to act longer on the post-synaptic receptor. Acetylcholine is a major neurotransmitter for memory, attention and concentration.

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