Investigating IgE-mediated allergy usually involves interpretation of skin prick testing and serum allergen-specific IgE testing in the context of the patient’s history and physical examination.
- Investigation for IgE-mediated hypersensitivity usually takes the form of skin prick testing and/or serum-specific IgE testing.
- Skin prick testing is the gold standard for detection of allergen-specific IgE; however, testing for serum-specific IgE is more readily available in the primary care setting.
- Tests should always be interpreted in the context of a thorough history and physical examination.
- False-negative serum-specific IgE tests occur, and a negative serum test should not be used to exclude allergy if the history suggests immediate hypersensitivity.