Therapeutics clinic

Biologics and psoriasis today

Rowena Meani, Peter Foley


An updated version is available in the linked supplement


Biologic agents have emerged as alternative treatment options for patients with moderate-to-severe plaque psoriasis. These agents have shown good efficacy and are well tolerated.

Article Extract

Psoriasis is a chronic systemic immune-mediated inflammatory disease of unknown aetiology that manifests primarily in the skin. It affects approximately 2% of the Australian population and has a substantial negative impact on patients’ quality of life. Patients with localised limited disease can usually be managed satisfactorily with topical agents, whereas those with moderate-to-severe disease often require systemic treatment.1 Phototherapy and traditional systemic treatments, although often effective, can be associated with long-term cumulative toxicity. In addition, some patients have treatment-resistant disease, and patients themselves show high levels of dissatisfaction with standard approaches to treatment.2

Picture credit: © Carol & Mike Werner/Visuals Unlimited/SPL.