Melanomas with pigmented globules differ from moles in being asymmetrical and having a disordered multicomponent pattern.
A 35-year-old woman was seen two months postpartum with a mole, which had enlarged during her pregnancy, on her right thigh. The mole was longstanding and measured 6 mm in diameter (Figure 1). Dermoscopy showed a pigmented nodule with an asymmetrical outline including a flat peripheral component. There were numerous irregularly sized and shaped dark brown globules that coalesced and extended focally to the border. A patchy grey–white veil was present. Scattered blue–black dots could also be seen at one border (Figure 2). The surgical specimen showed large irregular nests of atypical pigmented melanocytes both within the epidermis and underlying dermis, with a lymphocytic infiltrate (Figure 3).