Peer Reviewed
Feature Article Haematology
Low vitamin B12: what does it mean and what should I do?
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B vitamins
B vitamins
Abstract
A low vitamin B12 level is a common finding, and interpreting its significance can be difficult. A low level should never be ignored because deficiency may be responsible for occult haematological or neuropsychiatric disease.
Key Points
- Low vitamin B12 levels do not always indicate deficiency, but they should be investigated.
- Low vitamin B12 levels are common in elderly patients, but the clinical significance may be difficult to determine.
- It is possible that vitamin B12 deficiency may be responsible for cases of minor cognitive impairment, as well as the more classic neurological manifestations.
- There is concern that the widespread use of folic acid therapy and dietary supplementation may precipitate clinical disease in individuals with occult vitamin B12 deficiency
- Vitamin B12 assay results should always be interpreted in relation to the clinical context.
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