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Thursday 21 November 2024

Peer Reviewed

Gastroenterology clinic

Hepatitis C and obesity: a weighty issue

Venessa Pattullo

Recent articles on:
Hepatitis C

Part 5. Practical steps in your practice

Part 4. Ongoing care after hepatitis C treatment

Part 3. Curing hepatitis C in general practice

Part 2. Assessing your patient for antiviral treatment

Part 1. Finding your patients with hepatitis C

Recent articles on:
Obesity

New pharmacological treatments for obesity: incretin analogues, their mechanism of action, efficacy and safety

Obesity and cardiovascular disease: improving health outcomes

Concurrent management of type 2 diabetes and obesity

Obesity, atrial fibrillation and cardiovascular risk: a classic trifecta

Managing obesity – looking beyond lifestyle interventions

Abstract

Hepatitis C virus is directly implicated in the development of insulin resistance which, along with obesity, is associated with a worse prognosis in chronic hepatitis C and poorer response to interferon–ribavirin therapy.

Key Points

Remember

Obesity (body mass index, BMI, of 30 kg/m² or more) is common in patients with chronic hepatitis C; it has been found in up to 28.8% of patients. Obesity is associated with the metabolic complications of insulin resistance and type 2 diabetes.
Hepatitis C virus (HCV) has been directly implicated in the development of virus-mediated insulin resistance and therefore, in itself, increases the risk of type 2 diabetes.
HCV infection and obesity occurring concurrently thus compound the risk of developing insulin resistance and type 2 diabetes.