Sibutramine produces significant reduction in body weight and central adiposity, and improves some cardiovascular risk factors.
Obesity has become a growing problem in Australia over the last two decades, and the prevalence is expected to increase. Obesity causes and exacerbates many chronic medical conditions, including diabetes, hypertension, dyslipidaemia, arthritis, asthma, sleep apnoea and cardiovascular disease. Patients usually seek treatment because of the perceived medical consequences, social stigma and psychological and physical discomforts. In obese people, weight loss has substantial benefits with improvements in mobility, dyspnoea, cardiovascular risk factors, confidence and psychological wellbeing.