Peer Reviewed
Feature Article Rheumatology
Investigating the patient with a positive antinuclear antibody
Recent articles on:
Autoimmune diseases
Autoimmune diseases
Recent articles on:
Laboratory tests
Laboratory tests
Abstract
A positive ANA result does not always mean autoimmune disease. Here is how to interpret the test correctly.
Key Points
- The ANA test is a sensitive test, important in confirming a clinical impression of autoimmune disease. However, a positive result is not specific for autoimmune disease and may not be relevant to the patient’s presenting problems.
- The correct interpretation of a positive ANA depends on a thorough history and physical examination, careful consideration of the clinical situation, and appropriate laboratory investigations.
- The ANA titre and staining pattern are less important in determining the relevance of the test result.
- A positive ANA may be due to early, undifferentiated autoimmune disease.
- A positive ANA can be found in normal healthy individuals. The incidence of a positive ANA increases with age.
Purchase the PDF version of this article
Already a subscriber? Login here.