Familial hypercholesterolaemia increases the risk of premature atherosclerotic cardiovascular disease (ASCVD). Early diagnosis and appropriate treatment are the cornerstones of management. GPs can facilitate continuity of care, including screening, cascade testing, ASCVD risk stratification and lipid management.

In people with diabetes, identifying diabetic kidney disease early and implementing effective treatments can minimise the progression of renal dysfunction and associated comorbidities.

Resistant hypertension is challenging to treat and is associated with an increased risk of cardiovascular disease and organ damage. A guideline-recommended approach can help in the accurate diagnosis and comprehensive management of resistant hypertension.

Major advances have occurred in the pharmacological management of type 2 diabetes, with the introduction of new medications that improve glycaemia (and have a low risk of hypoglycaemia), promote weight loss and provide cardio-kidney protection.

A 38-year-old woman presents with class III obesity, hypertension and newly diagnosed atrial fibrillation (AF) with rapid ventricular response. GPs are encouraged to consider AF ablation as a treatment option in suitable patients.