In recent years, barely a week goes by without another report linking use of proton pump inhibitors with adverse health outcomes, yet they remain among the most used classes of drugs worldwide. What is the story? Are they safe or not, and who should take them?
- The effectiveness of proton pump inhibitors (PPIs) – esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole – for specific indications has been established over many years, with many evidence-based guidelines available. The most common indication is for suspected or proven gastro-oesophageal reflux disease (GORD).1