Peer Reviewed
Feature Article Endocrinology and metabolism

Restless legs syndrome

Catherina L Chang, Roo Killick, Brendon J Yee
Abstract
Restless legs syndrome (RLS) is a common movement disorder and many patients with the condition complain of disturbed sleep. Nonpharmacological management approaches alone may be appropriate for patients with milder RLS but those with more severe disease require pharmacological management. Non-ergot derived dopamine agonists are regarded as first-line treatment for patients with moderate to severe daily symptoms of RLS.
Key Points
  • Restless legs syndrome (RLS) is a common movement disorder and can be distressing for patients.
  • Diagnosis is clinical and based on clear diagnostic criteria.
  • Secondary causes of RLS such as iron deficiency and medications precipitating symptoms should be sought and treated.
  • Nonpharmacological management options should be explored.
  • Non-ergot derived dopamine agonists are the treatment of choice if the patient has moderate to severe daily symptoms of RLS.
  • When using dopaminergic therapy, the lowest dose possible should be used to prevent augmentation.
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