Systemic lupus erythematosus: an improving prognosis
Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune inflammatory disorder of unknown aetiology. Its immunopathogenesis is characterised by B cell dysfunction, autoantibody production and immune complex deposition in affected organs. It is considered the prototypical connective tissue disorder. Although it can be fatal, overall the prognosis has improved dramatically over the past few decades.
This article reviews the diagnosis and management of SLE, including the new anti-B cell biological therapies.
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